Source: hcplive, JAMA
(COLUMBUS, Ohio) — High dose immunosuppressive therapy (HDIT) with autologous hematopoietic cell transplant (HCT) sustained relapsing remitting (RR) multiple sclerosis (MS) remission at 3 years, according to preliminary results published in JAMA Neurology.
Researchers from HALT MS study evaluated MS patients through 5 years after HCT in order to evaluate the safety, efficacy, and durability of MS disease stabilization through 3 years after HDIT/ HCT. This analysis is the pre specified 3-year interim from the trial, which enrolled 25 RRMS patients from various referral centers. The autologous peripheral blood stem cells grafts were CD34+ selected and then the participants received high dose treatment with carmustine, etoposide, cytarabine, and melphalan as well as rabbit antithymocyte globulin before autologous HCT.
The HALT MS trial aims for event free survival which the researchers defined as without death or disease activity from any one of the following: confirmed loss of neurologic function; clinical relapse; or new lesions observed on magnetic resonance imaging (MRI). The toxic effects were reported using the National Cancer Institute Common Terminology Criteria for Adverse Events.
“Theoretically, if you look at identical twins where one twin has MS, 75 percent of the time the other twin doesn’t have MS,” said study co author Michael Racke, MD, of Ohio State University, in a news release. “What we’re trying to do is make an MS patient their own identical twin that doesn’t have MS.”